Five people have been rushed to hospital after a car collided with them on Frederick Street at the junction with Rose Street and failed to stop.
The vehicle then made its way to Lothian Road and collided with a vehicle before coming to a stop.
Officers remain at the scene this morning and the areas remain closed off.
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A 36-year-old man has been arrested in connection with the incident.
A Police Scotland spokesperson said: “Around 12.40am on Sunday, 12 September, we received reports of five pedestrians being hit by a vehicle on Rose Street near its junction with Frederick Street in Edinburgh.
“Two men aged 39 and 60-years old, and three women aged 37, 22 and 65, were taken to Edinburgh Royal Infirmary for treatment where they all remain in stable conditions.
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“The vehicle did not stop at the scene and continued to Lothian Road where it was involved in a crash with another vehicle. No further people were injured.
“Officers arrested a 36-year-old man in connection with the incident. Enquires remain ongoing.
“Lothian Road remains closed up to the Western Approach junction.”