Emergency services are currently dealing with an accident on Princes Street near Lothian Road.
Local diversions are in place whilst the incident is deal with.
A Police Scotland spokesman said: “Police in Edinburgh are currently in attendance on Princes Street, at its junction with Lothian Road, following a serious road collision involving a bus and a bicycle.
“The incident happened around 8.30 a.m. today.
“The Scottish Ambulance service have also responded to the scene to treat the female cyclist for her injuries.
“Local road closures and diversion are currently in place and motorists are advised to avoid the area while Road Policing Officers continue their enquiries.”