Five people have been rushed to hospital after a car collided with them on Frederick Street at the junction with Rose Street and failed to stop.
The vehicle then made its way to Lothian Road and collided with a vehicle before coming to a stop.
Officers remain at the scene this morning and the areas remain closed off.
A 36-year-old man has been arrested in connection with the incident.
A Police Scotland spokesperson said: “Around 12.40am on Sunday, 12 September, we received reports of five pedestrians being hit by a vehicle on Rose Street near its junction with Frederick Street in Edinburgh.
“Two men aged 39 and 60-years old, and three women aged 37, 22 and 65, were taken to Edinburgh Royal Infirmary for treatment where they all remain in stable conditions.
“The vehicle did not stop at the scene and continued to Lothian Road where it was involved in a crash with another vehicle. No further people were injured.
“Officers arrested a 36-year-old man in connection with the incident. Enquires remain ongoing.
“Lothian Road remains closed up to the Western Approach junction.”